Main characters (Глава 1)

Misha Collins as Castiel. Angel.
A seraphim angel who is a close friend of the Winchesters. Unlike other angels, he treats people more favorably and doesn't neglect them. Possesses many superpowers.
Noname aka Victor as Vicky Lopez (Painter)
An ordinary person living in a small town. He is n't familiar with the supernatural, he isn't familiar with monsters, and he doesn't know about the existence of characters from the mythology of all countries, times and peoples. A local artist who, according to Castiel, creates the world on canvas. His first appearance is in Castiel's dream. In the course of events, the Angel realizes that it wasn't just a dream. As it turned out, the man from the dream turns out to be a real inhabitant of the earth.
Jensen Ackles as Dean Winchester Hunter
Eldest son of John and Mary Winchester, brother of Sam. In fact, it was Dean who raised his brother, considers himself responsible for Sam and protects him with all his might. Prefers to «hunt» rather than live a «normal» life. He is distinguished by his sense of humor, which does not leave him even in the most hopeless situations, although, in fact, he hides his true emotions behind jokes. Immeasurably loves his car — a 1967 Chevrolet Impala, which he calls «baby».
Jared Padalecki as Sam Winchester Hunter
Youngest son of John and Mary Winchester. Sam has always wanted to live a normal life and never have to deal with supernatural beings. Nomadic life isn't for him. The guy was always interested in studying and, unlike his brother, he was not an obedient soldier in the war against evil spirits. If Dean can be described as a daredevil, then Sam is more of an intellectual, he has a calmer character.

Ruth Connell as Rowena MacLeod
A powerful witch and Crowley's mother.
Mark Pellegrino as Lucifer
Also known as the Devil and Satan, the first fallen archangel and creator of demons, revered by them as a father.
Mark Sheppard as Crowley (Fergus MacLeod) Crossroad Demon, King of Hell
A powerful demon and the Crossroads King, Lilith's right hand and later the King of Hell. For the first time, Becky Rosen is mentioned, who said that the colt was given not to Lilith, but to Crowley. Unlike other demons, Crowley does not support Lucifer because he believes that Lucifer will kill them all after the people, and it's likely that he's right.
Samantha Smith as Mary Winchester
Her full name is Mary Sandra Winchester (née Campbell). Wife of John Winchester, mother of Sam and Dean Winchester.
Alexander Calvert as Jack (Nephilim, Son of lucifer)
Nephilim, biologically the son of Lucifer and Kelly Kline, but considers Castiel to be his father. Jack looks more like a mother than a father. He is not alien to sympathy and compassion. It is the Earth that Jack considers his home, and calls the Winchester brothers and Castiel his family, while other angels, including Lucifer, mean nothing to him.
Osric Chau as Kevin Tran
A student of great promise, but after being struck by lightning, he became a prophet and keeper of the Word of God.
Rob Benedict as Chuck Shurley
At first, he appears before the audience as a prophet, but later it turns out that he is the Lord himself.
Curtis Armstrong as Metatron
Angel, Scribe of God.
Richard Speight Jr. as Gabriel
He is the Trickster — one of the four archangels, the brother of Michael, Lucifer and Raphael. He fled to Earth because of the quarrels of the archangel brothers and pretended to be a magician (or trickster) for a long time.
Emily Swallow as Amara (Adult)
The physical embodiment of Darkness, the sister of God.
Lisa Berry as Billie
A reaper who helped the Winchester brothers. After being killed by Castiel, she became the new Death.
Felicia Day as Charlie Bradbury
Genius hacker, worked for Dick Roman. Helped Sam and Dean Winchester get confidential information about the Leviathans and Roman in particular.
Keith Szarabajka as Donatello Redfield
The second prophet of God after the death of Kevin Tran.
Alaina Huffman as Abaddon
Purebred demon. Knight of Hell, black-eyed. Creation of Lucifer. Claimed the throne of Hell. Killed by Dean Winchester with the First Blade.
Courtney Ford as Kelly Kline (Jack's mother)
An aide to President Jefferson Rooney with whom she had a close relationship. She became pregnant from Lucifer, who moved into her lover. Jack's mother — died giving birth to him.
Thunderbird Dinwiddie as Pamela Barnes (One of the horsemen of the apocalypse, Death)
Also known as the Pale Rider and the Angel of Death, the oldest and most powerful of the Four Horsemen of the Apocalypse, an ancient primal being of immense power.